Chronic Kidney Disease (CKD) or end stage renal failure has no cure and requires renal replacement therapy, that is, dialysis or kidney transplant. Many different factors and conditions can cause CKD including hypertension, diabetes, glomerulonephritis, polycystic kidney disease lupus etc.
Mesenchymal stem cells can integrate into renal tubular cells and can differentiate into mesangial cells. Moreover, these cells stimulate the kidney’s own stem cells (resident stem cells) and release growth factors which promote the survival of renal cells, thus, initiating a natural recovery.
- Fat and bone marrow is harvested and processed (see technique).
- The cocktail of various progenitor cells is delivered the feeding artery of both the kidneys (renal artery).
- Localization of renal artery before stem cells administration
Patients received one intra-arterial injection of 20 million cells in each kidney followed by 5 sittings of 60 million stem cells via intravenous injection.
- 80 % patients showed diagnostic laboratory data collection with measured statically significant improvements in BUN, Creatinine.
- patients with associated Type 2 diabetics achieved better blood sugar control along with renal improvement .
- Improvements in energy level, motivation, libido and sexual function were also observed.
- kidney function improvements started to be observed as early as by 4 weeks & were continued for 6 months.
- Creatinine: from average baseline of 148.6 μmol/l, to 120.2 μmol/l, in 80 %of patients
- UREA: from average baseline of 34.71 mmol/l, to 14.40mmol/l, in 80 %of patients
- Blood pressure was also well controlled and remained stable between 130‐155/90‐100 mmHg in 90 % patients having very pressures.
- GFR increased to the range of 5-12 mL/min/1.73m2 in 60 % of patients
- CBC became normal by 6 months in 50 % of patients
- Albumin and leukocytes in the urine were reduced to within normal limits by 4 months in 75 % of patients
- Color Doppler ultrasound showed size of both sides of kidney slightly increased with visible adequate blood flow in the both kidneys in 40 %
- Dialysis was reduced to 1-2 times a week from 4 times a week in 40 % of patients.